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LFCS Seminar: Sara Kalvala

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Compilation Issues in Synthetic Biology

  • LFCS Seminar
When Apr 30, 2013
from 04:00 PM to 05:00 PM
Where IF 4.31-33
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There has been much enthusiasm shown recently for the idea of designing genetic circuits which can be fabricated as DNA sequences and then transferred into host cells. There are now libraries of components which can be chosen off the shelf and commercial manufacturers can quickly create and ship desired DNA. In practice, however, the design of robust synthetic biological device is complex and many unexpected interactions can result  in cells that do not work as intended, resulting in a waste of time and resources.

In this talk I will discuss ways to make the process of creating synthetic genetic circuits less ad-hoc and more effective by the application of principles developed over many decades in the domain of program compilation. The use of constraints, types, and optimizations are part of the repertoire of computer scientists which have yet to have made an impact in Synthetic Biology; here I will describe some of our efforts at Warwick to bring these notions to bear into an interesting and exciting application area.

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