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LFCS Seminar: Wan Fokkink

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Executing Multi-cellular Development: Petri Net Model of the C.elegans Vulva

What
  • LFCS Seminar
When Oct 21, 2010
from 02:00 PM to 03:00 PM
Where 4.31/4.33
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Executing Multi-cellular Development:
Petri Net Model of the C.elegans Vulva

Wan Fokkink
Vrije Universiteit Amsterdam

Understanding the processes involved in multi-cellular pattern formation is a central problem of developmental biology, hopefully leading to new insights in e.g. the treatment of various diseases.  Defining suitable computational techniques for development modelling, able to perform in silico simulation experiments, is a challenging problem.

I will explain a coarse-grained, quantitative approach based on Petri nets, to mimic the behaviour of the biological processes during multicellular differentiation.  We have applied this approach to the well-studied process of C. elegans vulval development.  Our model correctly reproduces a large set of in vivo experiments with statistical accuracy.  It also generates gene expression time series in accordance with biological evidence.  Finally, we modelled the role of microRNA mir-61 during vulval development and predict its contribution in stabilising cell pattern formation.

http://www.few.vu.nl/~wanf/

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